Endocrine Abstracts

Introduction: Immune checkpoint inhibitors (ICIs) have gained popularity as a standard cancer treatment in recent years. IrAEs, or immune-related adverse events, are specific immunological side effects that are linked to ICIs. Thyroid dysfunction is a prevalent irAE, but the cause, severity, and clinical appearance might vary. The most frequent thyroid irAEs brought on by ICIs are destructive thyroiditis and hypothyroidism, whereas immune-related adrenal insuf...

Background and aims: Diffused endemic goiter (DEG) development is not always explained by increased TSH levels. Most DEG patients (pts) have normal TSH concentrations, with tendency to decreased T4 and normal or slightly elevated T3. In the present study levels of thyroid hormones (TH) in pts with various degrees of thyroid size (TS) and weak iodine deficiency (ID) were analyzed.Material and methods: In total DEG 137pts, aged 2–16 years were studied...